Article
Development of label-free electrochemical impedance spectroscopy for the detection of HLA-B*15:02 and HLA-B*15:21 for the prevention of carbamazepine-induced Stevens-Johnson syndrome.
Analytical biochemistry - 1 Dec 2022
Chomean Sirinart, Nakkam Nontaya, Tassaneeyakul Wichittra, Attapong Jirapat, Kaset Chollanot
Abstract excerpt
BACKGROUND: Carbamazepine (CBZ) is an FDA-approved anticonvulsant that is widely used to treat epilepsy, bipolar disorder, trigeminal neuralgia and chronic pain. Several studies have reported a strong association between HLA-B*15:02 and carbamazepine-induced Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). However, the HLA-B75 serotype (HLA-B*15:02, HLA-B*15:08, HLA-B*15:11 and HLA-B*15:21) has...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.