Article
Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing.
Clinical pharmacology and therapeutics - 1 Sept 2013
Leckband S G, Kelsoe J R, Dunnenberger H M, George A L, Tran E, Berger R, Müller D J, Whirl-Carrillo M, Caudle K E, Pirmohamed M
Abstract excerpt
Human leukocyte antigen B (HLA-B) is a gene that encodes a cell surface protein involved in presenting antigens to the immune system. The variant allele HLA-B*15:02 is associated with an increased risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in response to carbamazepine treatment. We summarize evidence from the published literature supporting this association and provide...
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