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Article

Accurate identification of HLA-B*15:02 allele by two-dimensional polymerase chain reaction.

Clinica chimica acta; international journal of clinical chemistry - 1 Jan 2024

Zhu Xueting, Yu Yang, Zhang Jun, Zhan Yuxia, Luo Guanghua, Zheng Lu

Abstract excerpt

BACKGROUND: HLA-B*15:02 is highly associated with carbamazepine-induced SJS/TEN; however, there is no rapid and accurate detecting method. Here, we present a method to distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. METHODS: The high-throughput two-dimensional polymerase chain reaction (2D-PCR) technology was employed to identify HLA-B*15:02 in two-tube reaction. And, 2D-PCR accuracy was...

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Identifiers

PMID: 37972805
DOI: 10.1016/j.cca.2023.117654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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