Article
External quality assessment for laboratory testing of HLA-B*15:02 allele in relation to carbamazepine therapy.
Journal of clinical laboratory analysis - 1 Feb 2018
Lin Guigao, Zhang Kuo, Han Yanxi, Xie Jiehong, Li Jinming
Abstract excerpt
BACKGROUND: Due to the significant risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), the use of carbamazepine is not recommended in patients carrying the human leukocyte antigen B (HLA-B) *15:02 allele. In an effort to guarantee reliable community-based HLA-B*15:02 testing throughout China, a HLA-B*15:02 genotyping external quality assessment (EQA) program was set up....
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