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Article

An interdigitated electrode biosensor platform for rapid HLA-B*15:02 genotyping for prevention of drug hypersensitivity.

Biosensors & bioelectronics - 15 Jul 2018

Soraya Gita V, Chan Jianxiong, Nguyen Thanh C, Huynh Duc H, Abeyrathne Chathurika D, Chana Gursharan, Todaro Marian, Skafidas Efstratios, Kwan Patrick

Abstract excerpt

Prevention of life threatening hypersensitivity reactions to carbamazepine is possible through pre-treatment screening of the associated HLA-B*15:02 risk allele. However, clinical implementation of screening is hindered by the high cost and slow turnaround of conventional HLA typing methods. We have developed an interdigitated electrode (IDE) biosensor platform utilizing loop mediated isothermal amplification...

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PMID: 29673585
DOI: 10.1016/j.bios.2018.01.063

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IDE

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