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Article

Molecular identification of HLA-B75 serotype markers by qPCR: A more inclusive pharmacogenetic approach before carbamazepine prescription.

Clinical and translational science - 1 Jun 2024

Jaruthamsophon Kanoot, Sangmanee Pornsiri, Plong-On Oradawan, Charalsawadi Chariyawan, Sukasem Chonlaphat, Hnoonual Areerat

Abstract excerpt

Genetic screening for HLA-B*15:02 before prescribing carbamazepine is standard practice to prevent severe cutaneous adverse reactions in Asian populations. These reactions are associated not only with this allele but also with closely related HLA-B75 serotype markers-HLA-B*15:11 and HLA-B*15:21-which are prevalent in several Asian countries. However, a reliable method for identifying HLA-B75 serotype markers is...

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Identifiers

PMID: 38894615
DOI: 10.1111/cts.13867
PMCID: PMC11187875

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