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Article

Mendelian randomization analysis to examine for a causal effect of urate on bone mineral density.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2015

Dalbeth Nicola, Topless Ruth, Flynn Tanya, Cadzow Murray, Bolland Mark J, Merriman Tony R

Abstract excerpt

In observational studies, serum urate concentrations are positively associated with bone mineral density (BMD) and reduced risk of fragility fractures, raising the possibility that urate is a direct mediator of bone density. We used Mendelian randomization analysis to examine whether urate has a causal effect on BMD. We analyzed data from the Generation 3 cohort in the Framingham Heart Study (FHS) (N = 2501...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gout, Hyperuricemia, Uric Acid

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Source

Identifiers

PMID: 25502344
DOI: 10.1002/jbmr.2434

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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