Article
A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure.
Human genetics - 1 Jun 2015
Turpeinen Hannu, Seppälä Ilkka, Lyytikäinen Leo-Pekka, Raitoharju Emma, Hutri-Kähönen Nina, Levula Mari, Oksala Niku, Waldenberger Melanie, Klopp Norman, Illig Thomas, Mononen Nina, Laaksonen Reijo, Raitakari Olli, Kähönen Mika, Lehtimäki Terho, Pesu Marko
Abstract excerpt
Proprotein convertase subtilisin/kexin (PCSK) enzymes cleave and convert their immature substrates into biologically active forms. Polymorphisms in the PCSK genes have been reported to associate with human diseases and phenotypes, including hypercholesterolemia and blood pressure (BP), and target...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.