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Article

Increased inflammatory response both in brain and in periphery in presenilin 1 and presenilin 2 conditional double knock-out mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2009

Jiang Xu, Zhang Dongli, Shi Jianting, Chen Yiqun, Zhang Ping, Mei Bing

Abstract excerpt

It has been reported that conditional double knockout of presenilin-1 and presenilin-2 in forebrain of mice (dKO mice) induce symptoms most analogous to that of neurodegenerative diseases, especially Alzheimer's disease, however, there is no deposition of extra amyloid-beta (Abeta(40) or Abeta(42)) in dKO brain. In the present study, we thoroughly measured the inflammatory response in dKO mice, which is another...

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Source

Identifiers

PMID: 19584449
DOI: 10.3233/JAD-2009-1164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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