Article
Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites.
Malaria journal - 12 Jun 2007
Dahlbäck Madeleine, Lavstsen Thomas, Salanti Ali, Hviid Lars, Arnot David E, Theander Thor G, Nielsen Morten A
Abstract excerpt
BACKGROUND: The var multigene family encodes PfEMP1, which are expressed on the surface of infected erythrocytes and bind to various host endothelial receptors. Antigenic variation of PfEMP1 plays a key role in malaria pathogenesis, a process partially controlled at the level of var gene transcription. Transcriptional levels, throughout the intra-erythrocytic cycle, of 59 var genes of the NF54 clone were measured...
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