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Article

Natural variation in macrophage polarization and function impact pneumocyte senescence and susceptibility to fibrosis

28 Sept 2022

Abstract excerpt

Radiation-induced pulmonary fibrosis (RIPF), a late adverse event of radiation therapy, is characterized by infiltration of inflammatory cells, progressive loss of alveolar structure, secondary to the loss of pneumocytes and accumulation of collagenous extracellular matrix, and senescence of alveolar stem cells. Differential susceptibility to lung injury from radiation and other toxic insults across mouse strains...

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PMID: 36173617
DOI: 10.18632/aging.204309

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