Article
A mechanism for oxidative damage repair at gene regulatory elements.
Nature - 1 Sept 2022
Ray Swagat, Abugable Arwa A, Parker Jacob, Liversidge Kirsty, Palminha Nelma M, Liao Chunyan, Acosta-Martin Adelina E, Souza Cleide D S, Jurga Mateusz, Sudbery Ian, El-Khamisy Sherif F
Abstract excerpt
Oxidative genome damage is an unavoidable consequence of cellular metabolism. It arises at gene regulatory elements by epigenetic demethylation during transcriptional activation1,2. Here we show that promoters are protected from oxidative damage via a process mediated by the nuclear mitotic apparatus protein NuMA (also known as NUMA1). NuMA exhibits genomic occupancy approximately 100 bp around transcription...
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