Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolic enzyme IMPDH is also a transcription factor regulated by cellular state.

Molecular cell - 13 Jul 2012

Kozhevnikova Elena N, van der Knaap Jan A, Pindyurin Alexey V, Ozgur Zeliha, van Ijcken Wilfred F J, Moshkin Yuri M, Verrijzer C Peter

Abstract excerpt

Cells need to coordinate gene expression and metabolic state. Inosine monophosphate dehydrogenase (IMPDH) controls the guanine nucleotide pool and, thereby, cell proliferation. We found that Drosophila IMPDH is also a DNA-binding transcriptional repressor. IMPDH attenuates expression of histone g...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Chromatin Immunoprecipitation
Share to DNA, Single-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to E2F Transcription Factors

Share to G2 Phase

Share to Histones

Share to IMP Dehydrogenase

Share to Retinitis Pigmentosa

Source

Identifiers

PMID: 22658723
DOI: 10.1016/j.molcel.2012.04.030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22658723-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolic enzyme IMPDH is also a transcription factor regulated by cellular state.PMID 22658723Read ↗

IMPDH dysregulation in disease: a mini review.Semantic proximity Read ↗

IMP dehydrogenase-linked retinitis pigmentosa.Semantic proximity Read ↗

Different characteristics and nucleotide binding properties of inosine monophosphate dehydrogenase (IMPDH) isoforms.Semantic proximity Read ↗

IMPDH1 retinal variants control filament architecture to tune allosteric regulationSemantic proximity Read ↗

Light-sensitive phosphorylation regulates enzyme activity and filament assembly of human IMPDH1 retinal splice variantsSemantic proximity Read ↗

MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cellsSemantic proximity Read ↗

Why Do Mutations in the Ubiquitously Expressed Housekeeping Gene<i>IMPDH1</i>Cause Retina-Specific Photoreceptor Degeneration?Semantic proximity Read ↗

An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somitogenesisSemantic proximity Read ↗

Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions.Semantic proximity Read ↗

Retinal isoforms of inosine 5'-monophosphate dehydrogenase type 1 are poor nucleic acid binding proteins.Semantic proximity Read ↗

Regulation of an IMP dehydrogenase gene and its overexpression in drug-sensitive transcription elongation mutants of yeast.Semantic proximity Read ↗

Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.