Article
SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation.
PloS one - 1 Jan 2015
Hayakawa Tomohisa, Iwai Mika, Aoki Satoshi, Takimoto Koichi, Maruyama Mitsuo, Maruyama Wakako, Motoyama Noboru
Abstract excerpt
Senescent cells develop a pro-inflammatory response termed the senescence-associated secretory phenotype (SASP). As many SASP components affect surrounding cells and alter their microenvironment, SASP may be a key phenomenon in linking cellular senesence with individual aging and age-related diseases. We herein demonstrated that the expression of Sirtuin1 (SIRT1) was decreased and the expression of SASP...
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