Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development.

doi:10.1073/pnas.1210730109

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Article

Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development.

Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2012

Lage Kasper, Greenway Steven C, Rosenfeld Jill A, Wakimoto Hiroko, Gorham Joshua M, Segrè Ayellet V, Roberts Amy E, Smoot Leslie B, Pu William T, Pereira Alexandre C, Mesquita Sonia M, Tommerup Niels, Brunak Søren, Ballif Blake C, Shaffer Lisa G, Donahoe Patricia K, Daly Mark J, Seidman Jonathan G, Seidman Christine E, Larsen Lars A

Abstract excerpt

Congenital heart disease (CHD) occurs in ∼1% of newborns. CHD arises from many distinct etiologies, ranging from genetic or genomic variation to exposure to teratogens, which elicit diverse cell and molecular responses during cardiac development. To systematically explore the relationships between CHD risk factors and responses, we compiled and integrated comprehensive datasets from studies of CHD in humans and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hand Deformities, Congenital

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Identifiers

PMID: 22904188
DOI: 10.1073/pnas.1210730109
PMCID: PMC3435181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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