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Article

Sperm-inherited H3K27me3 epialleles are transmitted transgenerationally in cis.

Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2022

Kaneshiro Kiyomi Raye, Egelhofer Thea A, Rechtsteiner Andreas, Cockrum Chad, Strome Susan

Abstract excerpt

The transmission of chromatin states from parent cells to daughter cells preserves cell-specific transcriptional states and thus cell identity through cell division. The mechanism that underpins this process is not fully understood. The role that chromatin states serve in transmitting gene expression information across generations via sperm and oocytes is even less understood. Here, we utilized a model in which...

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Identifiers

PMID: 36161922
DOI: 10.1073/pnas.2209471119
PMCID: PMC9546627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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