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Article

Ubiquitin, cellular inclusions and their role in neurodegeneration.

Trends in neurosciences - 1 Dec 1998

Alves-Rodrigues A, Gregori L, Figueiredo-Pereira M E

Abstract excerpt

Covalent binding of ubiquitin to proteins marks them for degradation by the ubiquitin/ATP-dependent pathway. This pathway plays a major role in the breakdown of abnormal proteins that result from oxidative stress, neurotoxicity and mutations. Failure to eliminate ubiquitinated proteins disrupts cellular homeostasis, causing degeneration. Inclusions containing ubiquitinated proteins are commonly detected in many...

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PMID: 9881849
DOI: 10.1016/s0166-2236(98)01276-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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