Ubiquitin, cellular inclusions and their role in neurodegeneration.

doi:10.1016/s0166-2236(98)01276-4

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Article

Ubiquitin, cellular inclusions and their role in neurodegeneration.

Trends in neurosciences - 1 Dec 1998

Alves-Rodrigues A, Gregori L, Figueiredo-Pereira M E

Abstract excerpt

Covalent binding of ubiquitin to proteins marks them for degradation by the ubiquitin/ATP-dependent pathway. This pathway plays a major role in the breakdown of abnormal proteins that result from oxidative stress, neurotoxicity and mutations. Failure to eliminate ubiquitinated proteins disrupts c...

Topics

Animals
Endosomes
Humans
Inclusion Bodies
Lysosomes
Models, Molecular
Mutation
Neurodegenerative Diseases
Neurons
Reactive Oxygen Species
Ubiquitins

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