Article
Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis.
The European respiratory journal - 1 May 2017
Juge Pierre-Antoine, Borie Raphaël, Kannengiesser Caroline, Gazal Steven, Revy Patrick, Wemeau-Stervinou Lidwine, Debray Marie-Pierre, Ottaviani Sébastien, Marchand-Adam Sylvain, Nathan Nadia, Thabut Gabriel, Richez Christophe, Nunes Hilario, Callebaut Isabelle, Justet Aurélien, Leulliot Nicolas, Bonnefond Amélie, Salgado David, Richette Pascal, Desvignes Jean-Pierre, Lioté Huguette, Froguel Philippe, Allanore Yannick, Sand Olivier, Dromer Claire, Flipo René-Marc, Clément Annick, Béroud Christophe, Sibilia Jean, Coustet Baptiste, Cottin Vincent, Boissier Marie-Christophe, Wallaert Benoit, Schaeverbeke Thierry, Dastot le Moal Florence, Frazier Aline, Ménard Christelle, Soubrier Martin, Saidenberg Nathalie, Valeyre Dominique, Amselem Serge, Boileau Catherine, Crestani Bruno, Dieudé Philippe
Abstract excerpt
Despite its high prevalence and mortality, little is known about the pathogenesis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Given that familial pulmonary fibrosis (FPF) and RA-ILD frequently share the usual pattern of interstitial pneumonia and common environmental risk factors, we hypothesised that the two diseases might share additional risk factors, including FPF-linked genes. Our...
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