Article
Nasal epithelial gene expression identifies relevant asthma endotypes in the ATLANTIS study.
Thorax - 18 Sept 2024
Karp Tatiana, Faiz Alen, van Nijnatten Jos, Kerstjens Huib A M, Boudewijn Ilse, Kraft Monica, Vonk Judith M, Nawijn Martijn C, Heijink Irene H, Beghé Bianca, Rabe Klaus F, Papi Alberto, Brightling Chris, Singh Dave, van der Molen Thys, Siddiqui Salman, Christenson Stephanie, Guryev Victor, van den Berge Maarten
Abstract excerpt
INTRODUCTION: Asthma is an inflammatory airways disease encompassing multiple phenotypes and endotypes. Several studies suggested gene expression in nasal epithelium to serve as a proxy for bronchial epithelium, being a non-invasive approach to investigate lung diseases. We hypothesised that molecular differences in upper airway epithelium reflect asthma-associated differences in the lower airways and are...
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