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Article

FGF receptor inhibitor BGJ398 partially rescues osteoarthritis-like phenotype in older high molecular weight FGF2 transgenic mice via multiple mechanisms.

Scientific reports - 24 Sept 2022

Hurley Marja M, Coffin J Douglas, Doetschman Thomas, Valera Christina, Clarke Kai, Xiao Liping

Abstract excerpt

We have used Basic Fibroblast Growth Factor (FGF2) transgenic mice as experimental models for human X-linked hypophosphatemia (XLH)-related degenerative osteoarthritis (OA) to investigate the pathogenesis of the disease and to test potential pharmacotherapies for treatment. This study tested the efficacy of BJG398, a small molecule fibroblast growth factor receptor tyrosine kinase (FGFRTK) inhibitor, to rescue...

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Share to Core Binding Factor Alpha 1 Subunit
Share to Familial Hypophosphatemic Rickets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Matrix Metalloproteinase 13

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Source

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Identifiers

PMID: 36153352
DOI: 10.1038/s41598-022-20269-6
PMCID: PMC9509331

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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