Article

Zika viruses encode multiple upstream open reading frames in the 5′ viral region with a role in neurotropism

2017-03-02

Abstract excerpt

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus recently associated with congenital diseases and neurological complications. As for all flaviviruses, the ZIKV RNA genome is expected to encode a single polyprotein with all the enzymatic activities required for viral replication. Here, we report the discovery of multiple non-canonical open reading frames (ORFs) identified by ribosome profiling. In both ma...

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Literature Corpus work: 7b367471-e4f8-5df0-8fc3-f0e9dcde2f29
DOI: 10.1101/112904

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