Article

Complement system alteration in iPSC-derived astrocytes from individuals with Down syndrome

2024-10-28

Abstract excerpt

<title>Abstract</title> <p>Down syndrome (DS), or trisomy 21 (T21), resulting from an extra copy of chromosome 21, occurs in 1 in 700–1,000 live births. Neuroinflammation is increasingly recognized as a critical contributor to DS neuropathology, although its underlying drivers remain unclear. In this study, we analyzed available single-nucleus RNA sequencing data from <italic>postmortem</italic> cortical brain sa...

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Literature Corpus work: 5961ff5c-ed06-5c05-88f6-8d8fe06e5d9a
DOI: 10.21203/rs.3.rs-5319960/v1

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