Article
Genetic variation in NFE2L2 is associated with outcome following aneurysmal subarachnoid haemorrhage.
European journal of neurology - 1 Jan 2023
Gaastra Ben, Duncan Poppy, Bakker Mark K, Hostettler Isabel C, Alg Varinder S, Houlden Henry, Ruigrok Ynte M, Galea Ian, Tapper Will, Werring David, Bulters Diederik
Abstract excerpt
BACKGROUND AND PURPOSE: Nuclear factor erythroid 2-related factor 2 (NRF2; encoded by the NFE2L2 gene) has been implicated in outcome following aneurysmal subarachnoid haemorrhage (aSAH) through its activity as a regulator of inflammation, oxidative injury and blood breakdown product clearance. The aim of this study was to identify whether genetic variation in NFE2L2 is associated with clinical outcome following...
Topics
- Humans
- Subarachnoid Hemorrhage
- NF-E2-Related Factor 2
- Polymorphism, Single Nucleotide
- Genotype
- Alleles