Article
Associations between endothelin polymorphisms and aneurysmal subarachnoid hemorrhage, clinical vasospasm, delayed cerebral ischemia, and functional outcome.
Journal of neurosurgery - 1 May 2018
Griessenauer Christoph J, Starke Robert M, Foreman Paul M, Hendrix Philipp, Harrigan Mark R, Fisher Winfield S, Vyas Nilesh A, Lipsky Robert H, Lin Mingkuan, Walters Beverly C, Pittet Jean-Francois, Mathru Mali
Abstract excerpt
OBJECTIVE Endothelin-1, a potent vasoconstrictor, and its receptors may be involved in the pathogenesis of aneurysmal subarachnoid hemorrhage (aSAH), clinical vasospasm, delayed cerebral ischemia (DCI), and functional outcome following aSAH. In the present study, common endothelin single nucleotide polymorphisms (SNPs) and their relation to aSAH were evaluated. METHODS Blood samples from all patients enrolled in...
Topics
- Brain Ischemia
- Endothelin-1
- Female
- Follow-Up Studies
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Intracranial Aneurysm
- Male