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Article

Malignant clonal evolution drives multiple myeloma cellular ecological diversity and microenvironment reprogramming

22 Sept 2022

Abstract excerpt

BACKGROUND: Multiple myeloma (MM) is a heterogeneous disease with different patterns of clonal evolution and a complex tumor microenvironment, representing a challenge for clinicians and pathologists to understand and dissect the contribution and impact of polyclonality on tumor progression. METHODS: In this study, we established a global cell ecological landscape of the bone marrow (BM) from MM patients,...

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PMID: 36131282
DOI: 10.1186/s12943-022-01648-z

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