Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

African Swine Fever Virus MGF505-7R Interacts with Interferon Regulatory Factor 9 to Evade the Type I Interferon Signaling Pathway and Promote Viral Replication

23 Feb 2023

Abstract excerpt

ASF, caused by ASFV, is currently prevalent in Eurasia, with mortality rates reaching 100% in pigs. At present, there are no safe or effective vaccines against ASFV. In this study, we found that the ASFV protein MGF505-7R hinders IFN-β signaling by interacting with IRF9 and inhibiting the formation of ISGF3 heterotrimers. Of note, we demonstrated that MGF505-7R plays a role in the immune evasion of ASFV in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Disease Management and Epidemiology
Share to Vector-Borne Animal Diseases
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36815839
DOI: 10.1128/jvi.01977-22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

African Swine Fever Virus MGF505-7R Interacts with Interferon Regulatory Factor 9 to Evade the Type I Interferon Signaling Pathway and Promote Viral ReplicationPMID 36815839Read ↗

Multifunctional pMGF505-7R Is a Key Virulence-Related Factor of African Swine Fever VirusSemantic proximity Read ↗

African swine fever virus MGF505-7R protein interacted with IRF7and TBK1 to inhibit type I interferon productionSemantic proximity Read ↗

African Swine Fever Virus E120R Protein Inhibits Interferon Beta Production by Interacting with IRF3 To Block Its Activation.Semantic proximity Read ↗

African swine fever virus pB475L evades host antiviral innate immunity via targeting STAT2 to inhibit IFN-I signalingSemantic proximity Read ↗

MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling PathwaySemantic proximity Read ↗

Deletions of MGF110-9L and MGF360-9L from African swine fever virus are highly attenuated in swine and confer protection against homologous challengeSemantic proximity Read ↗

Combinational Deletions of MGF110-9L and MGF505-7R Genes from the African Swine Fever Virus Inhibit TBK1 Degradation by an Autophagy Activator PIK3C2B To Promote Type I Interferon ProductionSemantic proximity Read ↗

African swine fever virus MGF505-3R inhibits cGAS-STING-mediated IFN-β pathway activation by degrading TBK1Semantic proximity Read ↗

pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infectionSemantic proximity Read ↗

Modulation of Host Antiviral Innate Immunity by African Swine Fever Virus: A ReviewSemantic proximity Read ↗

African Swine Fever Virus: A ReviewSemantic proximity Read ↗

African Swine Fever Virus: a new old enemy of EuropeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.