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Article

Lack of L-type amino acid transporter 2 in murine thyroid tissue induces autophagy.

Journal of molecular endocrinology - 1 Jan 2023

Venugopalan Vaishnavi, Rehders Maren, Weber Jonas, Rodermund Lisa, Al-Hashimi Alaa, Bargmann Tonia, Golchert Janine, Reinecke Vivien, Homuth Georg, Völker Uwe, Verrey Francois, Kirstein Janine, Heuer Heike, Schweizer Ulrich, Braun Doreen, Wirth Eva K, Brix Klaudia

Abstract excerpt

Proteolytic cleavage of thyroglobulin (Tg) for thyroid hormone (TH) liberation is followed by TH release from thyroid follicles into the circulation, enabled by TH transporters. The existence of a functional link between Tg-processing cathepsin proteases and TH transporters has been shown to be independent of the hypothalamus-pituitary-thyroid axis. Thus, lack of cathepsin K, combined with genetic defects in the...

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PMID: 36129170
DOI: 10.1530/JME-22-0060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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