Article
Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.
Journal of cellular physiology - 1 May 2003
Chiellini Chiara, Costa Mario, Novelli Silvia E, Amri Ez-Zoubir, Benzi Luca, Bertacca Anna, Cohen Paul, Del Prato Stefano, Friedman Jeffrey M, Maffei Margherita
Abstract excerpt
In obesity, adipocytes undergo dramatic morphological and molecular changes associated with alterations in their gene expression profile. To identify genes differentially modulated in white adipose tissue (WAT) of obese db/db mice compared to wild type (wt) mice, we utilized RNA fingerprinting. Among the 52 candidates that we identified, we focused here on cathepsin K (ctsk), a cysteine protease, prevalently...
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