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Article

Ultrasensitive and visual detection of human norovirus genotype GII.4 or GII.17 using CRISPR-Cas12a assay.

Virology journal - 17 Sept 2022

Qian Weidong, Huang Jie, Wang Ting, Fan Cheng, Kang Jie, Zhang Qian, Li Yongdong, Chen Si

Abstract excerpt

BACKGROUND: Integrating CRISPR-Cas12a sensors with isothermal signal amplification can be exploited to develop low-cost, disposable, and ultrasensitive assays for the diagnostics of human pathogens. METHODS: RT-RAA-Cas12a-mediated real-time or end-point fluorescent and lateral flow strip (LFS) assays for direct detection of norovirus (NOV) genotype GII.4 or GII.17 were explored. RESULTS: The results showed that...

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Identifiers

PMID: 36115975
DOI: 10.1186/s12985-022-01878-z
PMCID: PMC9482751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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