Article
EZH2 inhibitory protein (EZHIP/Cxorf67) expression correlates strongly with H3K27me3 loss in posterior fossa ependymomas and is mutually exclusive with H3K27M mutations.
Brain tumor pathology - 1 Jan 2021
Nambirajan Aruna, Sharma Agrima, Rajeshwari Madhu, Boorgula Meher Tej, Doddamani Ramesh, Garg Ajay, Suri Vaishali, Sarkar Chitra, Sharma Mehar Chand
Abstract excerpt
The PFA molecular subgroup of posterior fossa ependymomas (PF-EPNs) shows poor outcome. H3K27me3 (me3) loss by immunohistochemistry (IHC) is a surrogate marker for PFA wherein its loss is attributed to overexpression of Cxorf67/EZH2 inhibitory protein (EZHIP), C17orf96, and ATRX loss. We aimed to subgroup PF-EPNs using me3 IHC and study correlations of the molecular subgroups with other histone related proteins,...
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