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Article

Loss of MLL Induces Epigenetic Dysregulation of Rasgrf1 to Attenuate Kras-Driven Lung Tumorigenesis.

Cancer research - 15 Nov 2022

Zhu Ling-Yu, Yuan Jun-Bo, Zhang Li, He Chun-Xiao, Lin Xiao, Xu Bin, Jin Guang-Hui

Abstract excerpt

Menin is necessary for the formation of the menin/mixed lineage leukemia (MLL) complex and is recruited directly to chromatin. Menin is an important tumor suppressor in several cancer types, including lung cancer. Here, we investigated the role of MLL in menin-regulated lung tumorigenesis. Ablation of MLL suppressed KrasG12D-induced lung tumorigenesis in a genetically engineered mouse model. MLL deficiency...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myeloid-Lymphoid Leukemia Protein

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Source

Identifiers

PMID: 36098964
DOI: 10.1158/0008-5472.CAN-22-1475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of MLL Induces Epigenetic Dysregulation of Rasgrf1 to Attenuate Kras-Driven Lung Tumorigenesis.PMID 36098964Read ↗

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