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Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition

18 Mar 2025

Abstract excerpt

Targeting the dependency of MLL-rearranged (MLLr) leukemias on menin with small molecule inhibitors has opened new therapeutic strategies for these poor-prognosis diseases. However, the rapid development of menin inhibitor resistance calls for combinatory strategies to improve responses and prevent resistance. Here we show that leukemia stem cells (LSCs) of MLLr acute myeloid leukemia (AML) exhibit enhanced...

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PMID: 40102405
DOI: 10.1038/s41467-025-57544-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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