Genetic variation in CD36, HBA, NOS3 and VCAM1 is associated with chronic haemolysis level in sickle cell anaemia: a longitudinal study.

doi:10.1111/ejh.12226

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Article

Genetic variation in CD36, HBA, NOS3 and VCAM1 is associated with chronic haemolysis level in sickle cell anaemia: a longitudinal study.

European journal of haematology - 1 Mar 2014

Coelho Andreia, Dias Alexandra, Morais Anabela, Nunes Baltazar, Ferreira Emanuel, Picanço Isabel, Faustino Paula, Lavinha João

Abstract excerpt

Chronic haemolysis stands out as one of the hallmarks of sickle cell anaemia, a clinically heterogeneous autosomal recessive monogenic anaemia. However, the genetic architecture of this sub-phenotype is still poorly understood. Here, we report the results of an association study between haemolysis biomarkers (serum LDH, total bilirubin and reticulocyte count) and the inheritance of 41 genetic variants of ten...

Topics

Alleles
Anemia, Sickle Cell
CD36 Antigens
Child
Erythrocytes
Female
Genotype
Haplotypes
Hemoglobin A
Hemoglobins
Hemolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homozygote

Humans

Longitudinal Studies

Male

Nitric Oxide

Nitric Oxide Synthase Type III

Phenotype

Source

Open in PubMed

Identifiers

PMID: 24168396
DOI: 10.1111/ejh.12226

Genes

VCAM1
NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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