Article
Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae.
Nature medicine - 1 May 2020
Ernst Christoph M, Braxton Julian R, Rodriguez-Osorio Carlos A, Zagieboylo Anna P, Li Li, Pironti Alejandro, Manson Abigail L, Nair Anil V, Benson Maura, Cummins Kaelyn, Clatworthy Anne E, Earl Ashlee M, Cosimi Lisa A, Hung Deborah T
Abstract excerpt
Among the most urgent public health threats is the worldwide emergence of carbapenem-resistant Enterobacteriaceae1-4, which are resistant to the antibiotic class of 'last resort'. In the United States and Europe, carbapenem-resistant strains of the Klebsiella pneumoniae ST258 (ref. 5) sequence type are dominant, endemic6-8 and associated with high mortality6,9,10. We report the global evolution of pathogenicity...
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