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Article

Absence of genetic association between insulin-like growth factors and esophageal cancer.

Medicine - 27 Dec 2024

Sun Zhengliang, Wang Xiaohong

Abstract excerpt

This study aimed to explore the causal relationship between concentrations of various insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) and esophageal cancer (ESC), addressing the gap in understanding the genetic link between IGF1 and ESC. A two-sample Mendelian randomization (MR) analysis was conducted using single nucleotide polymorphisms linked to IGFs/IGFBPs and ESC from the IEU Open GWAS...

Read the complete abstract on PubMed

Topics

Female
Humans
Male
Esophageal Neoplasms
Genetic Predisposition to Disease
Genome-Wide Association Study
Insulin-Like Growth Factor Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Insulin-Like Growth Factor I

Insulin-Like Peptides

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

Somatomedins

White People

Source

Open in PubMed Open full text

Identifiers

PMID: 39969361
DOI: 10.1097/MD.0000000000040899
PMCID: PMC11688069

Genes

IGF1
IGF1R
IGFBP3
IGFBPL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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