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Article

RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro.

Journal of lipid research - 1 Oct 2022

Yuan Xiaofan, Xiao Hongmei, Hu Qingzhe, Shen Guanru, Qin Xinyue

Abstract excerpt

Repulsive guidance molecule a (RGMa) is a glycosylphosphatidylinositol-anchored glycoprotein that has been demonstrated to influence inflammatory-related diseases in addition to regulating neuronal differentiation and survival during brain development. However, any function or mechanism of RGMa in dedifferentiation of contractile vascular smooth muscle cells (VSMCs) during inflammatory-related atherosclerosis is...

Topics

Mice
Animals
Muscle, Smooth, Vascular
Neointima
Plaque, Atherosclerotic
Glycosylphosphatidylinositols
Cell Proliferation
Myocytes, Smooth Muscle
Lipoproteins, LDL
Phenotype
Apolipoproteins E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrophages

Transcription Factors

RNA, Messenger

Cell Movement

Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 36089003
DOI: 10.1016/j.jlr.2022.100276
PMCID: PMC9587411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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