Article
Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2017
Tian Hongyu, Ketova Tatiana, Hardy Duriel, Xu Xiaojiang, Gao Xia, Zijlstra Andries, Blobe Gerard C
Abstract excerpt
OBJECTIVE: Endoglin, a transforming growth factor-β superfamily coreceptor, is predominantly expressed in endothelial cells and has essential roles in vascular development. However, whether endoglin is also expressed in vascular smooth muscle cells (VSMCs), especially in vivo, remains controversial. Furthermore, the roles of endoglin in VSMC biology remain largely unknown. Our objective was to examine the...
Topics
- Animals
- CRISPR-Cas Systems
- Cell Movement
- Cell Shape
- Cells, Cultured
- Coculture Techniques
- Endoglin
- Endothelial Cells
- Focal Adhesion Kinase 1
- Gene Expression Regulation
- Humans
- Integrins
- Mice, Inbred C57BL