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Article

Insights into Allosteric Mechanisms of the Lung-Enriched p53 Mutants V157F and R158L.

International journal of molecular sciences - 3 Sept 2022

Lei Jiangtao, Li Xuanyao, Cai Mengqiang, Guo Tianjing, Lin Dongdong, Deng Xiaohua, Li Yin

Abstract excerpt

Lung cancer is a leading fatal malignancy in humans. p53 mutants exhibit not only loss of tumor suppressor capability but also oncogenic gain-of-function, contributing to lung cancer initiation, progression and therapeutic resistance. Research shows that p53 mutants V157F and R158L occur with high frequency in lung squamous cell carcinomas. Revealing their conformational dynamics is critical for developing novel...

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PMID: 36077492
DOI: 10.3390/ijms231710100
PMCID: PMC9456101

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