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mPR-Specific Actions Influence Maintenance of the Blood–Brain Barrier (BBB)

26 Aug 2022

Abstract excerpt

Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial microvascular sinusoids that result in increased susceptibility to hemorrhagic stroke. It has been demonstrated that three CCM proteins (CCM1, CCM2, and CCM3) form the CCM signaling complex (CSC) to mediate angiogenic signaling. Disruption of the CSC will result in hemorrhagic CCMs, a consequence of compromised...

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Share to Intracerebral and Subarachnoid Hemorrhage Research
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PMID: 36077089
DOI: 10.3390/ijms23179684

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