Article

High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins

2024-12-05

Abstract excerpt

<h4>ABSTRACT</h4> Cerebral cavernous malformations (CCMs) are clusters of thin-walled enlarged blood vessels in the central nervous system that are prone to recurrent hemorrhage and can occur in both sporadic and familial forms. The familial form results from loss-of-function variants in the CCM1 , CCM2 , or CCM3 gene. Despite a better understanding of CCM pathogenesis in recent years, it is still unclear why...

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Literature Corpus work: 5989adb5-18ce-546a-8329-b83ab5e80b0a
DOI: 10.1101/2024.12.04.626588

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