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Article

A Longitudinal Study of the Association between the LEPR Polymorphism and Treatment Response in Patients with Bipolar Disorder.

International journal of molecular sciences - 25 Aug 2022

Chang Hui Hua, Hsueh Yuan-Shuo, Cheng Yung Wen, Tseng Huai-Hsuan

Abstract excerpt

Patients with bipolar disorder (BD) exhibit individual variability in the treatment outcome, and genetic background could contribute to BD itself and the treatment outcome. Leptin levels significantly change in BD patients treated with valproate (VPA), but whether LEPR polymorphisms are associated with treatment response is still unknown. This longitudinal study aimed to investigate the associations between LEPR...

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Identifiers

PMID: 36077028
DOI: 10.3390/ijms23179635
PMCID: PMC9455965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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