Article
A longitudinal study of the association between the GNB3 C825T polymorphism and metabolic disturbance in bipolar II patients treated with valproate.
The pharmacogenomics journal - 1 Mar 2017
Chen P S, Chang H H, Huang C-C, Lee C C, Lee S-Y, Chen S-L, Huang S-Y, Yang Y K, Lu R-B
Abstract excerpt
This longitudinal study aimed to investigate the associations between the polymorphisms of guanine nucleotide-binding protein subunit β-3 (GNB3) C825T and metabolic disturbance in bipolar II disorder (BP-II) patients being treated with valproate (VPA). A 100 BP-II patients received a 12-week course of VPA treatment, and their body weight and metabolic indices were measured. At baseline, the GNB3 C825T...
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