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White spot syndrome virus protein ICP11: A histone-binding DNA mimic that disrupts nucleosome assembly

18 Dec 2008

Abstract excerpt

White spot syndrome virus (WSSV) is a large ( approximately 300 kbp), double-stranded DNA eukaryotic virus that has caused serious disease in crustaceans worldwide. ICP11 is the most highly expressed WSSV nonstructural gene/protein, which strongly suggests its importance in WSSV infection; but until now, its function has remained obscure. We show here that ICP11 acts as a DNA mimic. In crystal, ICP11 formed a...

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PMID: 19095797
DOI: 10.1073/pnas.0811233106

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