Article
The antiretroviral agents azidothymidine, stavudine, and didanosine have the identical mutational fingerprint in the rpoB region of Escherichia coli.
Environmental and molecular mutagenesis - 1 Aug 2022
Yaramada Lekha, Singh Sunjum, Ge Zoe, Shin Jeana, Mashiach Daniel, Miller Jeffrey H
Abstract excerpt
We looked at the mutational fingerprints of three antiretroviral (anti-HIV) agents, azidothymidine (AZT), stavudine (STAV), and didanosine (DIDA) in the rpoB system of Escherichia coli and compared them with each other and with the fingerprints of trimethoprim and of spontaneous mutations in a wild-type and a mutT background. All three agents gave virtually identical fingerprints in the wild-type background,...
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