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Heterogeneity and viral replication fitness of HSV-1 clinical isolates with mutations in the thymidine kinase and DNA polymerase.

The Journal of antimicrobial chemotherapy - 28 Oct 2022

Schalkwijk Hanna Helena, Gillemot Sarah, Reynders Marijke, Selleslag Dominik, Andrei Graciela, Snoeck Robert

Abstract excerpt

BACKGROUND: Prolonged antiviral therapy in immunocompromised individuals can result in the emergence of (multi)drug-resistant herpes simplex virus 1 (HSV-1) infections, forming a therapeutic challenge. OBJECTIVES: To evaluate spatial and temporal differences in drug resistance of HSV-1 samples from a HSCT recipient and to determine the effect of resistance mutations on viral replication fitness. PATIENTS AND...

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Identifiers

PMID: 36059135
DOI: 10.1093/jac/dkac297

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