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Article

A Herpes Simplex Virus 1 DNA Polymerase Multidrug Resistance Mutation Identified in a Patient With Immunodeficiency and Confirmed by Gene Editing.

The Journal of infectious diseases - 28 Nov 2023

Schalkwijk Hanna Helena, Georgala Aspasia, Gillemot Sarah, Temblador Arturo, Topalis Dimitri, Wittnebel Sebastian, Andrei Graciela, Snoeck Robert

Abstract excerpt

BACKGROUND: Herpes simplex virus 1 can cause severe infections in individuals who are immunocompromised. In these patients, emergence of drug resistance mutations causes difficulties in infection management. METHODS: Seventeen herpes simplex virus 1 isolates were obtained from orofacial/anogenital lesions in a patient with leaky severe combined immunodeficiency over 7 years, before and after stem cell...

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PMID: 37224525
DOI: 10.1093/infdis/jiad184

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