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Article

Evaluation of Genotypic Antiviral Resistance Testing as an Alternative to Phenotypic Testing in a Patient with DOCK8 Deficiency and Severe HSV-1 Disease.

The Journal of infectious diseases - 11 Jun 2020

Casto Amanda M, Stout Sean C, Selvarangan Rangaraj, Freeman Alexandra F, Newell Brandon D, Stahl Erin D, Ahmed Atif A, Greninger Alexander L, Yin Dwight E

Abstract excerpt

Antiviral resistance frequently complicates the treatment of herpes simplex virus (HSV) infections in immunocompromised patients. Here we present the case of an adolescent boy with dedicator of cytokinesis 8 (DOCK8) deficiency, who experienced recurrent infections with resistant HSV-1. We used both phenotypic and genotypic methodologies to characterize the resistance profile of HSV-1 in the patient and conclude...

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Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Guanine Nucleotide Exchange Factors

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Share to Herpesvirus 1, Human

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Source

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Identifiers

PMID: 31970398
DOI: 10.1093/infdis/jiaa020
PMCID: PMC7289554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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