Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterogeneity and evolution of thymidine kinase and DNA polymerase mutants of herpes simplex virus type 1: implications for antiviral therapy.

The Journal of infectious diseases - 15 Apr 2013

Andrei Graciela, Georgala Aspasia, Topalis Dimitri, Fiten Pierre, Aoun Michel, Opdenakker Ghislain, Snoeck Robert

Abstract excerpt

BACKGROUND: Infections caused by acyclovir-resistant isolates of herpes simplex virus (HSV) after hematopoietic stem cell transplantation (HSCT) are an emerging concern. An understanding of the evolutionary aspects of HSV infection is crucial to the design of effective therapeutic and control strategies. METHODS: Eight sequential HSV-1 isolates were recovered from an HSCT patient who suffered from recurrent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyclovir
Share to Drug Resistance, Multiple, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ganciclovir

Share to Genes, pol

Share to Genetic Heterogeneity

Share to Hematopoietic Stem Cell Transplantation

Share to Herpesvirus 1, Human

Share to Thymidine Kinase

Source

Identifiers

PMID: 23315323
DOI: 10.1093/infdis/jit019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity and evolution of thymidine kinase and DNA polymerase mutants of herpes simplex virus type 1: implications for antiviral therapy.PMID 23315323Read ↗

Heterogeneity and viral replication fitness of HSV-1 clinical isolates with mutations in the thymidine kinase and DNA polymerase.Semantic proximity Read ↗

Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients.Semantic proximity Read ↗

Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance.Semantic proximity Read ↗

Sequential switching of DNA polymerase and thymidine kinase-mediated HSV-1 drug resistance in an immunocompromised child.Semantic proximity Read ↗

Clinical and genotypic characteristics of antiviral-resistant herpes simplex virus 1 and 2 infections: a case series.Semantic proximity Read ↗

Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients.Semantic proximity Read ↗

Resistance of herpes simplex viruses to acyclovir: an update from a ten-year survey in France.Semantic proximity Read ↗

Herpes simplex virus resistance to antiviral drugs.Semantic proximity Read ↗

Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2.Semantic proximity Read ↗

"The end of innocence" revisited: resistance of herpesviruses to antiviral drugs.Semantic proximity Read ↗

Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms.Semantic proximity Read ↗

Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.