Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequential switching of DNA polymerase and thymidine kinase-mediated HSV-1 drug resistance in an immunocompromised child.

Antiviral therapy - 1 Feb 2004

Stránská Růzena, van Loon Anton M, Bredius Robbert G M, Polman Merjo, Nienhuis Elske, Beersma Matthias F C, Lankester Arjan C, Schuurman Rob

Abstract excerpt

Sequential herpes simplex virus type 1 (HSV-1) isolates were obtained from a paediatric haematopoietic stem cell transplant (HSCT) patient who received prolonged therapy with acyclovir (ACV) followed by foscarnet (PFA) and topical cidofovir (HPMPC) for severe persistent mucocutaneous HSV-1 infect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpes Simplex
Share to Herpesvirus 1, Human
Share to Immunocompromised Host

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sputum

Share to Stem Cell Transplantation

Share to Thymidine Kinase

Source

Identifiers

PMID: 15040541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15040541-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequential switching of DNA polymerase and thymidine kinase-mediated HSV-1 drug resistance in an immunocompromised child.PMID 15040541Read ↗

Heterogeneity and evolution of thymidine kinase and DNA polymerase mutants of herpes simplex virus type 1: implications for antiviral therapy.Semantic proximity Read ↗

Resistance of herpes simplex viruses to acyclovir: an update from a ten-year survey in France.Semantic proximity Read ↗

Single nucleotide polymorphisms of thymidine kinase and DNA polymerase genes in clinical herpes simplex virus type 1 isolates associated with different resistance phenotypes.Semantic proximity Read ↗

Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients.Semantic proximity Read ↗

Heterogeneity and viral replication fitness of HSV-1 clinical isolates with mutations in the thymidine kinase and DNA polymerase.Semantic proximity Read ↗

Characterization of herpes simplex viruses selected in culture for resistance to penciclovir or acyclovir.Semantic proximity Read ↗

Clinical and genotypic characteristics of antiviral-resistant herpes simplex virus 1 and 2 infections: a case series.Semantic proximity Read ↗

Herpes simplex virus resistance to antiviral drugs.Semantic proximity Read ↗

Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance.Semantic proximity Read ↗

Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades.Semantic proximity Read ↗

Surveillance of herpes simplex virus resistance to antivirals: a 4-year survey.Semantic proximity Read ↗

Evaluation of Genotypic Antiviral Resistance Testing as an Alternative to Phenotypic Testing in a Patient with DOCK8 Deficiency and Severe HSV-1 Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.