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Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations

2 Jan 2018

Abstract excerpt

BACKGROUND: Invasive cribriform and intraductal carcinoma (CR/IDC) is associated with adverse outcome of prostate cancer patients. The aim of this study was to determine the molecular aberrations associated with CR/IDC in primary prostate cancer, focusing on genomic instability and somatic copy number alterations (CNA). METHODS: Whole-slide images of The Cancer Genome Atlas Project (TCGA, N = 260) and the...

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PMID: 29295717
DOI: 10.1186/s12885-017-3976-z

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